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is an azaindole-based synthetic cannabinoid that has been offered online as a designer drug. It is believed to be a powerful agonist of the CB1 receptor, and its mechanism of action is unknown. It has a very tight connection to NNE1. In light of the fact that amantadine is known to be released during the metabolic process of the related compound APINACA and also to be present in APINACA as an impurity, it is hypothesized that the metabolic hydrolysis of the amide group of 5F-PCN may result in the release of 1-naphthylamine, which is a known carcinogen.
In the United States, AM-2201 is being used for recreational purposes, which has led to it being explicitly included in a proposed amendment to the Controlled Substances Act from 2011. This proposal is intended to place a variety of synthetic substances into Schedule I. Acute renal failure, brain damage, strokes, convulsions, seizures, rhabdomyolysis, and death are among the acute toxicity and long term adverse effects linked with the usage of AM-2201.
It produces effects in animals that are similar to those of tetrahydrocannabinol (THC), which is a cannabinoid that is naturally present in cannabis. As a result, it is used in synthetic cannabis products such as “legal cannabis herbal incense blends,” which are sold legally as “incense” in some countries, with the label “not for human consumption.”
It is standard practice to smoke or vape cannabinoids in order to hasten the onset of their effects and hasten their wear off. Oral administration of JWH-018 that has been dissolved in a lipid makes it active, and this may greatly extend its effects. It has the same property as other cannabinoids in that it does not dissolve in water but does dissolve in ethanol and lipids.
When compared to cannabinoids derived from cannabis, synthetic cannabinoids have been shown to be related with a greater number of fatalities, as well as more serious side effects and toxicity in general. Because of this, it is highly advised against consuming this drug for a lengthy period of time or in quantities that are considered unsafe.
Synthetic cannabis JWH-018, also known as naphthalen-1-yl-(1-pentylindol-3-yl)methanone, is characterized by the presence of a substituted indole structural motif. This indole core is shared by a number of different cannabis compounds, such as PB-22, 5F-PB-22, JWH-018, and AM2201. At position R1, JWH-018 has a pentyl chain replaced for it. In addition to this, the indole core has a carbonyl group attached to the R3 position, and this carbonyl group is also connected to the napthalene moiety. The molecular structure of napthalene may be described as a bicyclic compound with two fused benzene rings. Because of the presence of a carbonyl bridge in JWH-018, it is classified as a ketone. The core indazole structure of JWH-018 has been replaced with an indole base, making it an analog of THJ-018, which was described above.
AM-678 is a complete agonist of the CB1 and CB2 cannabinoid receptors, with a binding affinity of 9.00 5.00 nM at the CB1 receptor and 2.94 2.65 nM at the CB2 receptor, respectively. On the other hand, the function of these interactions and how they contribute to the cannabis high experience continue to be poorly understood.