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This product is designed to be used as a reference standard for analytical purposes.
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Synonyms\s5-fluoro An analytical reference substance known as QUPIC 5-fluoro PB-22 (Item No. 14095) is a synthetic cannabinoid that fits the structural definition of the term (CB). The pEC50 values for human CB1 and CB2 receptor activation are 8.55 and 7.97, respectively, when this compound is present. In rats, 1,2 5-fluoro PB-22 mimics the in vivo effects of delta-9-tetrahydrocannabinol (THC) by potently and dose-dependently inducing hypothermia and decreasing heart rate. (Item Nos. 12068 | ISO60157) 1 This product is designed to be used in scientific and forensic investigations.
This item is a certified Reference Material (RM) that has been made and examined to ensure that it complies with the standards set out in ISO17025 and Guide 34. In order to guarantee the accuracy of the measurements, these materials go through a series of tests in which their validity as analytic materials is verified using approved apparatus. All RMs that may be traced can be differentiated by their respective CofAs, which can be retrieved here by utilizing the batch number that is printed on the product label. To get a representative CofA, kindly get in touch with our technical assistance.
PB-22, also known as QUPIC or 1-pentyl-1H-indole-3-carboxylic acid 8-quinolinyl ester, is a synthetic cannabimimetic medication that is marketed by internet merchants as a cannabimimetic agent. In 2013, PB-22 was found to be being sold in synthetic cannabis products in Japan. Although the origins of PB-22’s design are unknown, its structure seems to be based on an awareness of the structural-activity connections that exist within the indole class of cannabimimetic [original research?]. Because it has an ester linker at the indole 3-position, rather than the precedented ketone seen in JWH-018 and its analogs or the amide found in APICA and its analogs, PB-22 is a structurally distinctive example of a chemotype of synthetic cannabis.
For human CB1 receptors, the EC50 value for PB-22 is 5.1 nM, whereas the EC50 value for human CB2 receptors is 37 nM. At dosages of 0.3–3 mg/kg, PB-22 induces bradycardia and hypothermia in rats, which is consistent with the presence of significant cannabinoid-like action. The degree and duration of hypothermia that was caused in rats by PB-22 were noticeably larger than that which was induced by JWH-018, AM-2201, UR-144, XLR-11, APICA, or STS-135, with a drop in body temperature still being evident six hours after the dose was administered. According to the findings of one clinical toxicological research, PB-22 was the factor that brought on seizures in both a person and his dog.