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A drug molecule belonging to the sunstituted cathinone family that is a stimulant and is also referred to as -methylamino-valerophenone. Since it was discovered to be a legal high for the very first time in 2010, it has a documented history of usage.
It is more formally known by the systematic name (RS)-1-phenyl-2-(methylamino)pentan-1-one, which comes from the IUPAC. At normal conditions of temperature and pressure, pentedrone hydrochloride takes the form of a white powder. Its chemical formula is C12H17NO, and its molar mass is determined to be 191.27 grams. The melting point of the hydrochloride salt is 1768 degrees Celsius, and it has a molar mass of 227.73 grams.
The chemical inhibits the reuptake of noradrenaline and dopamine, which is how it produces its stimulating impact in the body. This does not result in the discharge of the aforementioned neurochemicals. The pharmacological effect of this substance is comparable to that of methylphenidate.
It has been shown that pentedrone has rewarding characteristics in rats, which is consistent with the dopamenergic action that it possesses. In rats, it has been shown to increase the expression of dopamine 1 receptor, dopamine 2 receptor, and dopamine transporter proteins via the regulation of mRNA expression. This up-regulation is a fundamental homeostatic function of the body that plays an important role in the body’s ability to self-regulate and is an indication of excessive stimulation of the dopaminergic pathway.
It has been shown that mice’s conditioned place preference may be increased by pentedrone at doses of 3 and 10 mg/kg. This outcome is illustrative of the rewarding qualities that it has. It has also been shown that it may dramatically improve the rate of self-administration in rats when given as an infusion of 0.3 mg per kg. The acute delivery of pentedrone to rats results in a dose-dependent increase in the animals’ level of locomotor activity.
There is no information available on the toxicological profile of pentedrone in humans. There has been little research done on the long-term or even short-term consequences that recreational usage may have on one’s health.
Consumption of the substance by humans or animals is strictly prohibited.
Online reports that cannot be independently verified provide us with some idea of the effects of this substance.
In most cases, the reports of usage highlight a variety of beneficial impacts that the chemical has. It is said to generate sensations of pleasure, stimulation of the mind and body, greater attention and mental clarity, as well as enhanced productivity.
A lack of appetite and minor abnormalities in the visual field are two of the neutral effects that have been recorded.
Anxiety, paranoia, severe agitation, palpitations of the heart and irregular heart beat, elevated heart rate, clenching of the jaw, and chilly extremities are some of the negative effects that have been recorded as a result of the usage of pentedrone.
Pentedrone has the potential to cause psychosis if it is ingested in large quantities or over an extended length of time. The condition in question is one that is referred to as amphetamine psychosis. Hallucinations, delusions, and thinking that is disorganized are some of the symptoms.
Pentedrone was shown to be a contributing factor in one fatality, which occurred when it was combined with another cathinone known as -PVP. The guy passed away due to complications from heart failure.
It is not advisable to mix Tramadol with pentedrone since doing so may raise the likelihood of having a seizure. People who are taking MAOI antidepressants on prescription should steer clear of pentedrone and other stimulants since consuming all three at the same time might lead to a hypertensive crisis.
It is not recommended to mix pentedrone with psychedelic stimulants of the DOx family or the NBOMe series because of the potential for dangerous interactions. It should not be used with DXM since both of these substances speed up the heart rate.
It is believed that pentedrone has a low potential for addiction but a significant potential for misuse.
The mucous membranes have been reported to experience irritation as a result of this.
Alternative titles and synonyms:
The 2-(methylamino)-1-phenyl-pentanone [ACD/Index Name]
2-(Methlamino)-1-phenyl-1-pentanon (German: 2-(Methlamino)-1-phenyl-1-pentanon) [Name of the ACD/IUPAC]
The IUPAC and ACD names for this compound are 2-(Methylamino)-1-phenyl-1-pentanone.
2-(Méthylamino)-1-phényl-1-pentanone [French] [Name of the ACD/IUPAC]
The RN number for 2-(methylamino)-1-phenylpentan-1-one is 879722-57-3.
879669-95-1 [RN] MFCD20663738 -methylaminovalerophenone -methylamino-valerophenone -methylaminovalerophenone
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